Photoreceptor Cell Specific Nuclear Receptor / PNR (NR2E3) Antibody
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Description
Nuclear Receptor Subfamily 2, Group E, Member 3 Antibody is a Rabbit Polyclonal antibody against Nuclear Receptor Subfamily 2, Group E, Member 3.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Photoreceptor Cell Specific Nuclear Receptor / PNR (NR2E3) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, containing 0.1% Sodium Azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9Y5X4 |
| Gene ID | 10002 |
| NCBI Accession | NP_055064.1, NM_014249.3, NP_057430.1, NM_016346.3 |
| OMIM | 268100 |
| Alias | PNR,RNR,rd7,ESCS,RP37,Retina-specific nuclear receptor,Photoreceptor-specific nuclear receptor |
| Background | Antibody anti-NR2E3 |
| Status | RUO |
Descripción
Nuclear receptor subfamily 2 group E member 3 (NR2E3), also known as photoreceptor-specific nuclear receptor, is a nuclear receptor involved in the regulation of retinal development and the function of photoreceptors in the eye NR2E3 is specifically expressed in the retina, where it regulates the differentiation of photoreceptor cells, including rods and cones It plays a critical role in the development of the retina by influencing the expression of genes involved in the differentiation and maintenance of photoreceptors, which are essential for vision NR2E3 also controls the transcriptional network that governs the survival of retinal cells and the response to light Inherited mutations in NR2E3 are associated with retinal degenerative diseases, such as retinitis pigmentosa, which leads to progressive vision loss by impairing photoreceptor function In addition, NR2E3’s role in regulating the development of other retinal cell types and maintaining visual function makes it an important factor in ocular health and a potential target for therapeutic interventions in retinal diseases
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