Photoreceptor Cell Specific Nuclear Receptor / PNR (NR2E3) Antibody
637€ (100 µl)
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Name
Photoreceptor Cell Specific Nuclear Receptor / PNR (NR2E3) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx114196
Tested Applications
ELISA, WB, IHC
Description
Nuclear Receptor Subfamily 2, Group E, Member 3 Antibody is a Rabbit Polyclonal antibody against Nuclear Receptor Subfamily 2, Group E, Member 3.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Photoreceptor Cell Specific Nuclear Receptor / PNR (NR2E3) Immunogen: Human NR2E3. |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, containing 0.1% Sodium Azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9Y5X4 |
| Gene ID | 10002 |
| NCBI Accession | NP_055064.1, NM_014249.3, NP_057430.1, NM_016346.3 |
| OMIM | 268100 |
| Alias | PNR,RNR,rd7,ESCS,RP37,Retina-specific nuclear receptor,Photoreceptor-specific nuclear receptor |
| Background | Antibody anti-NR2E3 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Nuclear receptor subfamily 2 group E member 3 (NR2E3), also known as photoreceptor-specific nuclear receptor, is a nuclear receptor involved in the regulation of retinal development and the function of photoreceptors in the eye NR2E3 is specifically expressed in the retina, where it regulates the differentiation of photoreceptor cells, including rods and cones It plays a critical role in the development of the retina by influencing the expression of genes involved in the differentiation and maintenance of photoreceptors, which are essential for vision NR2E3 also controls the transcriptional network that governs the survival of retinal cells and the response to light Inherited mutations in NR2E3 are associated with retinal degenerative diseases, such as retinitis pigmentosa, which leads to progressive vision loss by impairing photoreceptor function In addition, NR2E3’s role in regulating the development of other retinal cell types and maintaining visual function makes it an important factor in ocular health and a potential target for therapeutic interventions in retinal diseases
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