PHF10 Antibody (Biotin)
169€ (20 µg)
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935106861
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name
PHF10 Antibody (Biotin)
category
Primary Antibodies
provider
Abbexa
reference
abx304815
tested applications
ELISA
Description
PHF10 Antibody (Biotin) is a Rabbit Polyclonal against PHF10 conjugated to Biotin.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | PHF10 |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Biotin |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8WUB8 |
| Gene ID | 55274 |
| NCBI Accession | NP_060758.2, NM_018288.3, NP_579866.2, NM_133325.2 |
| OMIM | 613069 |
| Alias | BAF45A,SMARCG4,XAP135,BRG1-associated factor 45a |
| Background | Antibody anti-PHF10 |
| Status | RUO |
Descripción
PHF10 is a chromatin-remodeling protein that acts as a subunit of the BAF (SWI/SNF) complex, which regulates transcription by altering nucleosome positioning and chromatin accessibility. Through its PHD domain, PHF10 interacts with histone modifications, particularly methylated and acetylated histones, facilitating recruitment of chromatin remodeling factors to target loci. PHF10 plays a crucial role in processes such as cellular differentiation, proliferation, and DNA repair by modulating transcriptional programs in a cell-specific manner. It is highly expressed in neural and embryonic tissues, where it contributes to neural development and stem cell maintenance. Dysregulation of PHF10 is implicated in neurodevelopmental disorders, immune dysfunction, and cancers, particularly melanoma and glioblastoma, where aberrant chromatin remodeling leads to altered gene expression. Knockout studies reveal impaired cellular differentiation, reduced chromatin accessibility, and defective transcriptional regulation, underscoring its role in epigenetic control, development, and disease progression.
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