Recombinant Human PHF10

Background

PHF10 is a chromatin-remodeling protein that acts as a subunit of the BAF (SWI/SNF) complex, which regulates transcription by altering nucleosome positioning and chromatin accessibility. Through its PHD domain, PHF10 interacts with histone modifications, particularly methylated and acetylated histones, facilitating recruitment of chromatin remodeling factors to target loci. PHF10 plays a crucial role in processes such as cellular differentiation, proliferation, and DNA repair by modulating transcriptional programs in a cell-specific manner. It is highly expressed in neural and embryonic tissues, where it contributes to neural development and stem cell maintenance. Dysregulation of PHF10 is implicated in neurodevelopmental disorders, immune dysfunction, and cancers, particularly melanoma and glioblastoma, where aberrant chromatin remodeling leads to altered gene expression. Knockout studies reveal impaired cellular differentiation, reduced chromatin accessibility, and defective transcriptional regulation, underscoring its role in epigenetic control, development, and disease progression.