PHD Finger Protein 6 (PHF6) Antibody
364€ (100 µg)
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935106861
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name
PHD Finger Protein 6 (PHF6) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx236388
tested applications
ELISA, WB, IHC
Description
PHF6 Antibody is a Rabbit Polyclonal against PHF6.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | PHD Finger Protein 6 (PHF6) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1/500 - 1/2000, IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8IWS0 |
| Gene ID | 84295 |
| OMIM | 300414 |
| Alias | PHF6,CENP-31,KIAA1823,PHD-like zinc finger protein |
| Background | Antibody anti-PHF6 |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
PHF6 is a PHD finger domain-containing protein that functions in transcriptional regulation, chromatin remodeling, and cell cycle control. It interacts with components of chromatin-modifying complexes to facilitate gene silencing or activation, depending on cellular context. PHF6 is expressed in neural and hematopoietic tissues, where it regulates processes such as neurodevelopment, cell proliferation, and differentiation. Mutations in PHF6 are associated with Börjeson-Forssman-Lehmann syndrome, a neurodevelopmental disorder characterized by intellectual disability, epilepsy, and craniofacial abnormalities. PHF6 is also implicated in hematological cancers, including T-cell leukemia, where its loss of function disrupts chromatin organization and transcriptional regulation. Knockout studies demonstrate defects in neuronal development, impaired cell cycle progression, and increased genomic instability, highlighting its essential role in chromatin regulation, neurodevelopment, and disease pathogenesis.
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