PHD Finger Protein 21A (PHF21A) Antibody (FITC)
169€ (20 µg)
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Name
PHD Finger Protein 21A (PHF21A) Antibody (FITC)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx317093
Description
PHF21A Antibody (FITC) is a Rabbit Polyclonal against PHF21A conjugated to FITC.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: PHD Finger Protein 21A (PHF21A) Immunogen: Recombinant Human PHD finger protein 21A protein (312-487AA). |
| Host | Rabbit |
| Reactivity | Human |
| Detection Method | Laser Line: 488 Excitation/Emission: 499/515 |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | FITC |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q96BD5 |
| Gene ID | 51317 |
| NCBI Accession | NP_001095272.1, NM_001101802.1 |
| OMIM | 608325 |
| Alias | BHC80, BM-006, IDDBCS, NEDMS,BHC80a |
| Background | Antibody anti-PHF21A |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
PHF21A is a PHD finger-containing protein involved in chromatin remodeling and transcriptional repression through its interactions with histone modifications. It is a component of the BHC complex, where it facilitates histone deacetylation and demethylation to suppress gene expression. PHF21A plays an essential role in neural development, where it regulates genes involved in neuronal differentiation, synaptic plasticity, and brain formation. It binds to unmethylated CpG islands and recruits chromatin modifiers to maintain gene silencing in a tissue-specific manner. Dysregulation or mutations in PHF21A are associated with neurodevelopmental disorders, including intellectual disability and Potocki-Shaffer syndrome, which manifest as craniofacial abnormalities and cognitive impairments. Knockout studies reveal disrupted neuronal differentiation, altered gene silencing, and developmental defects, highlighting its role in transcriptional repression, neurodevelopment, and chromatin regulation.
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