PHD Finger Protein 21A (PHF21A) Antibody
312€ (60 µl)
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Name
PHD Finger Protein 21A (PHF21A) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx004838
Tested Applications
WB
Description
PHF21A Antibody is a Rabbit Polyclonal antibody against PHF21A. The PHF21A gene encodes BHC80, a component of a BRAF35 (MIM 605535)/histone deacetylase (HDAC; see MIM 601241) complex (BHC) that mediates repression of neuron-specific genes through the cis-regulatory element known as repressor element-1 (RE1) or neural restrictive silencer (NRS) (Hakimi et al., 2002.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: PHD Finger Protein 21A (PHF21A) Immunogen: Recombinant fusion protein corresponding to human PHF21A |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 70 kDa/74 kDa Observed MW: 70-80 kDa |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | WB |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q96BD5 |
| Gene ID | 51317 |
| NCBI Accession | NP_001095272.1 |
| Alias | BHC80, BM-006, IDDBCS, NEDMS,BHC80a |
| Background | Antibody anti-PHF21A |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
PHF21A is a PHD finger-containing protein involved in chromatin remodeling and transcriptional repression through its interactions with histone modifications. It is a component of the BHC complex, where it facilitates histone deacetylation and demethylation to suppress gene expression. PHF21A plays an essential role in neural development, where it regulates genes involved in neuronal differentiation, synaptic plasticity, and brain formation. It binds to unmethylated CpG islands and recruits chromatin modifiers to maintain gene silencing in a tissue-specific manner. Dysregulation or mutations in PHF21A are associated with neurodevelopmental disorders, including intellectual disability and Potocki-Shaffer syndrome, which manifest as craniofacial abnormalities and cognitive impairments. Knockout studies reveal disrupted neuronal differentiation, altered gene silencing, and developmental defects, highlighting its role in transcriptional repression, neurodevelopment, and chromatin regulation.
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