PHD Finger Protein 21A (PHF21A) Antibody

Este producto es parte de PHF - PHD finger protein
PHD Finger Protein 21A (PHF21A) Antibody

Pida mas información

935106861

info@markelab.com

Precio

364€ (100 µg)

Antibody anti-PHF21A

proveedor

Abbexa

reference

abx236386

Tested Applications

ELISA, WB

reactivity

Human, Mouse, Rat

status

RUO

clonality

Polyclonal

Descripción

PHF21A Antibody is a Rabbit Polyclonal against PHF21A.


Background

PHF21A is a PHD finger-containing protein involved in chromatin remodeling and transcriptional repression through its interactions with histone modifications. It is a component of the BHC complex, where it facilitates histone deacetylation and demethylation to suppress gene expression. PHF21A plays an essential role in neural development, where it regulates genes involved in neuronal differentiation, synaptic plasticity, and brain formation. It binds to unmethylated CpG islands and recruits chromatin modifiers to maintain gene silencing in a tissue-specific manner. Dysregulation or mutations in PHF21A are associated with neurodevelopmental disorders, including intellectual disability and Potocki-Shaffer syndrome, which manifest as craniofacial abnormalities and cognitive impairments. Knockout studies reveal disrupted neuronal differentiation, altered gene silencing, and developmental defects, highlighting its role in transcriptional repression, neurodevelopment, and chromatin regulation.

Características del producto

category

Primary Antibodies


clonality

Polyclonal


reactivity

Human, Mouse, Rat


immunogen target

PHD Finger Protein 21A (PHF21A)


host

Rabbit


isotype

IgG


conjugation

Unconjugated


form

Liquid


tested applications

ELISA, WB


purity

≥ 95% (SDS-PAGE)


purification

Purified by immunogen affinity chromatography.


recommended dilution

WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.


buffer

PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.


size 1

100 µg


storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.


or code

PHF21A


dry ice

No


availability

Shipped within 5-12 working days.


alias

BHC80, BM-006, IDDBCS, NEDMS,BHC80a


note

Concentration: 2 mg/ml - Validity: 12 months.


Quizá le pueda interesar

anti- PHF21A antibody

anti- PHF21A antibody

proveedor

FineTest

reference

FNab06386

Tested Applications

ELISA, WB

reactivity

human,mouse,rat

status

RUO

clonality

polyclonal

Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neurona...

Precio a consultar

Ver más

PHD Finger Protein 21A (PHF21A) Antibody

PHD Finger Protein 21A (PHF21A) Antibody

proveedor

Abbexa

reference

abx004838

Tested Applications

WB

reactivity

Human, Mouse, Rat

status

RUO

clonality

Polyclonal

PHF21A Antibody is a Rabbit Polyclonal antibody against PHF21A. The PHF21A gene encodes BHC80, a component of a BRAF35 (...

312€ (60 µl)

Ver más

PHD Finger Protein 21A (PHF21A) Antibody

PHD Finger Protein 21A (PHF21A) Antibody

proveedor

Abbexa

reference

abx028858

Tested Applications

ELISA, WB

reactivity

Human

status

RUO

clonality

Polyclonal

The PHF21A gene encodes BHC80, a component of a BRAF35 (MIM 605535) /histone deacetylase (HDAC; see MIM 601241) complex ...

292.5€ (80 µl)

Ver más