PHD Finger Protein 20 (PHF20) Antibody
364€ (100 µg)
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935106861
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name
PHD Finger Protein 20 (PHF20) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx236385
tested applications
ELISA, WB
Description
PHF20 Antibody is a Rabbit Polyclonal against PHF20.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | PHD Finger Protein 20 (PHF20) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9BVI0 |
| Gene ID | 51230 |
| OMIM | 610335 |
| Alias | PHF20,C20orf104,GLEA2,HCA58,NZF,TZP |
| Background | Antibody anti-PHF20 |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
PHF20 is a chromatin-binding protein that recognizes methylated histones, particularly H3K4me3 and H4K20me1, to regulate transcriptional activation, DNA repair, and cellular proliferation. It functions as a transcriptional co-activator by recruiting epigenetic modifiers and transcription machinery to target loci, ensuring precise gene expression during development and cellular responses. PHF20 is a key regulator of p53 stability and function, linking chromatin dynamics to tumor suppression and DNA damage responses. It is expressed in proliferative tissues and plays roles in stem cell maintenance, cell cycle regulation, and DNA repair. Dysregulation of PHF20 has been implicated in cancers, where its loss of function leads to genomic instability and uncontrolled proliferation. Knockout studies demonstrate defects in p53 signaling, impaired DNA repair, and reduced cellular proliferation, highlighting its essential role in chromatin regulation, tumor suppression, and transcriptional control.
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