PHD Finger Protein 17 (PHF17) Antibody
292.5€ (80 µl)
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935106861
info@markelab.com
name
PHD Finger Protein 17 (PHF17) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx027393
tested applications
ELISA, WB, IHC
Description
Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Transcriptional coactivator it may also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | PHD Finger Protein 17 (PHF17) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q6IE81 |
| Alias | KIAA1807,PHF17,PHD finger protein 17 |
| Background | Antibody anti-JADE1 |
| Status | RUO |
Descripción
JADE1 is a key chromatin-associated protein involved in histone acetylation and transcriptional regulation as part of the HBO1 histone acetyltransferase complex. Through its PHD finger domain, JADE1 recognizes acetylated histone H4 and facilitates H3/H4 acetylation, regulating chromatin accessibility during transcription, DNA replication, and repair. JADE1 is highly expressed in tissues undergoing rapid cell division, such as embryonic and epithelial tissues, where it controls cell cycle progression and differentiation. It is also involved in the Wnt/β-catenin signaling pathway, where it promotes the stabilization of β-catenin, influencing gene expression programs critical for development and tissue regeneration. Dysregulation of JADE1 is associated with cancer progression, fibrosis, and developmental disorders due to altered chromatin modification and transcriptional regulation. Knockdown studies demonstrate defects in histone acetylation, impaired cell cycle control, and disrupted transcriptional activation, highlighting its essential role in maintaining chromatin structure, epigenetic regulation, and cellular homeostasis.
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