PHD Finger Protein 16 (PHF16) Antibody

Background

JADE3 is a PHD finger-containing protein that plays a role in chromatin remodeling and transcriptional regulation through histone acetylation. Similar to JADE2, JADE3 is part of the HBO1 complex, where it facilitates histone H3/H4 acetylation during DNA replication and transcription. JADE3 contributes to the regulation of cell cycle progression, particularly the G1/S transition, by coordinating histone acetylation and chromatin accessibility at replication origins. It is expressed in embryonic and somatic tissues, where it supports gene activation programs during development and cellular differentiation. Dysregulation of JADE3 has been linked to cancer and developmental abnormalities due to impaired histone modification and cell cycle control. Functional studies reveal defects in replication initiation, reduced histone acetylation, and impaired transcriptional activation, underscoring its role as a critical regulator of chromatin dynamics and cell proliferation.