PHD Finger Protein 16 (PHF16) Antibody
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Description
This gene is part of a gene cluster on chromosome Xp11.23. The encoded protein contains a zinc finger motif often found in transcriptional regulators, however, its exact function is not known. Alternative splicing results in multiple transcript variants encoding the same protein.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | PHD Finger Protein 16 (PHF16) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q92613 |
| Alias | JADE3, KIAA0215, PHF16,Jade family PHD finger protein 3,PHD finger protein 16 |
| Background | Antibody anti-JADE3 |
| Status | RUO |
Descripción
JADE3 is a PHD finger-containing protein that plays a role in chromatin remodeling and transcriptional regulation through histone acetylation. Similar to JADE2, JADE3 is part of the HBO1 complex, where it facilitates histone H3/H4 acetylation during DNA replication and transcription. JADE3 contributes to the regulation of cell cycle progression, particularly the G1/S transition, by coordinating histone acetylation and chromatin accessibility at replication origins. It is expressed in embryonic and somatic tissues, where it supports gene activation programs during development and cellular differentiation. Dysregulation of JADE3 has been linked to cancer and developmental abnormalities due to impaired histone modification and cell cycle control. Functional studies reveal defects in replication initiation, reduced histone acetylation, and impaired transcriptional activation, underscoring its role as a critical regulator of chromatin dynamics and cell proliferation.
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