PHD Finger Protein 14 (PHF14) Antibody
364€ (100 µg)
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935106861
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name
PHD Finger Protein 14 (PHF14) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx236381
tested applications
ELISA, WB, IHC, IP
Description
PHF14 Antibody is a Rabbit Polyclonal against PHF14.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | PHD Finger Protein 14 (PHF14) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/500 - 1/2000, IHC: 1/20 - 1/200, IP: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IP |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O94880 |
| Gene ID | 9678 |
| Alias | PHF14, KIAA0783 |
| Background | Antibody anti-PHF14 |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
PHF14 is a nuclear protein that contains a PHD domain and is involved in chromatin-mediated gene regulation. It acts as a transcriptional regulator by binding to methylated histones, particularly H3K4me3, and recruiting chromatin modifiers to control gene expression. PHF14 regulates processes such as cell proliferation, differentiation, and tissue remodeling, particularly in fibroblasts and epithelial cells. It is widely expressed in embryonic and adult tissues, where it modulates developmental programs, tissue repair, and extracellular matrix organization. Dysregulation of PHF14 is linked to lung fibrosis, kidney disorders, and cancer, where it promotes abnormal proliferation and tissue remodeling by altering transcriptional programs. Knockout studies reveal defects in fibroblast proliferation, impaired organ development, and disrupted extracellular matrix organization, emphasizing its role in chromatin regulation, tissue homeostasis, and disease pathogenesis.
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