PHF14 antibody
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935106861
info@markelab.com
name
PHF14 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab06381
tested applications
ELISA, WB, IHC, IP
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | PHD finger protein 14 (PHF14) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 140-150 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC, IP |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | O94880 |
| Gene ID | 9678 |
| Alias | PHF14, KIAA0783 |
| Background | Antibody anti-PHF14 |
| Status | RUO |
| Note | Mol. Weight 140-150 kDa |
PHF14 is a nuclear protein that contains a PHD domain and is involved in chromatin-mediated gene regulation. It acts as a transcriptional regulator by binding to methylated histones, particularly H3K4me3, and recruiting chromatin modifiers to control gene expression. PHF14 regulates processes such as cell proliferation, differentiation, and tissue remodeling, particularly in fibroblasts and epithelial cells. It is widely expressed in embryonic and adult tissues, where it modulates developmental programs, tissue repair, and extracellular matrix organization. Dysregulation of PHF14 is linked to lung fibrosis, kidney disorders, and cancer, where it promotes abnormal proliferation and tissue remodeling by altering transcriptional programs. Knockout studies reveal defects in fibroblast proliferation, impaired organ development, and disrupted extracellular matrix organization, emphasizing its role in chromatin regulation, tissue homeostasis, and disease pathogenesis.
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