PHD Finger Protein 11 (PHF11) Antibody
169€ (20 µl)
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935106861
info@markelab.com
name
PHD Finger Protein 11 (PHF11) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx321909
tested applications
ELISA, WB, IHC
Description
PHF11 Antibody is a Rabbit Polyclonal against PHF11.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | PHD Finger Protein 11 (PHF11) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000 - 1/5000, IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 20 µl |
| Size 2 | 50 µl |
| Size 3 | 100 µl |
| Size 4 | 200 µl |
| Size 5 | 1 ml |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9UIL8 |
| Gene ID | 51131 |
| NCBI Accession | NP_001035533.1, NM_001040443.2 |
| OMIM | 147050 |
| Alias | PHF11,BCAP,NY-REN-34,IGER,BRCA1 C-Terminus-Associated Protein,Renal Carcinoma Antigen NY-REN-34,NYREN34,IGHER,IGEL,APY |
| Background | Antibody anti-PHF11 |
| Status | RUO |
Descripción
PHF11 is a PHD domain-containing protein involved in transcriptional regulation and immune responses. It interacts with transcription factors and chromatin modifiers to regulate the expression of genes associated with inflammation, immune cell activation, and DNA repair. PHF11 plays a key role in enhancing transcriptional activity at specific genomic loci, particularly in B cells and T cells, where it regulates immune responses, including cytokine production and class-switch recombination. It is highly expressed in lymphoid tissues, supporting its role in adaptive immunity and lymphocyte function. Dysregulation of PHF11 is associated with autoimmune diseases, inflammatory disorders, and cancer, where altered transcriptional regulation disrupts immune balance and cell proliferation. Knockout studies demonstrate impaired immune responses, reduced antibody production, and defective lymphocyte activation, highlighting its importance in transcriptional regulation, immune system maintenance, and adaptive immunity.
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