PHD Finger-Like Domain-Containing Protein 5A (PHF5A) Antibody
169€ (20 µg)
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935106861
info@markelab.com
name
PHD Finger-Like Domain-Containing Protein 5A (PHF5A) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx110087
tested applications
ELISA, IHC, IF/ICC
Description
PHD finger-like domain-containing protein 5A Antibody is a Rabbit Polyclonal antibody against PHD finger-like domain-containing protein 5A.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | PHD Finger-Like Domain-Containing Protein 5A (PHF5A) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | IHC: 1/20 - 1/200, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q7RTV0 |
| Gene ID | 84844 |
| Alias | NI, Rds3, SAP14b, SF3B7, SF3b14b, bK223H9.2,PHD finger-like domain protein 5A |
| Background | Antibody anti-PHF5A |
| Status | RUO |
Descripción
PHF5A is a chromatin-binding protein that interacts with histones through its PHD finger domain and serves as a core component of the spliceosome complex. It regulates alternative splicing of pre-mRNA, controlling the expression of genes involved in cell cycle progression, differentiation, and apoptosis. PHF5A is essential for the recognition of splice sites and the recruitment of splicing machinery during transcription. It is ubiquitously expressed in proliferating tissues, particularly in stem cells and cancer cells, where it maintains proper gene expression programs. Dysregulation of PHF5A has been implicated in cancer, including glioblastoma and leukemia, where it promotes tumor progression by modulating splicing events that regulate survival and proliferation. Knockdown studies reveal impaired splicing, reduced cell proliferation, and increased apoptosis, underscoring its role as a critical regulator of RNA processing, transcription, and cellular growth.
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