Peroxisome Proliferator Activated Receptor Delta (PPARD) Antibody
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935106861
info@markelab.com
Precio
175€ (20 µl)
Antibody anti-PPARD
proveedor
Abbexareference
abx004326Tested Applications
WB, IHCreactivity
Human, Mouse, Ratstatus
RUOclonality
PolyclonalDescripción
PPARD Antibody is a Rabbit Polyclonal antibody against PPARD. This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation. Alternate splicing results in multiple transcript variants.
Background
Peroxisome proliferator activated receptor delta (PPARD) is another member of the peroxisome proliferator-activated receptor family that regulates the expression of genes involved in lipid metabolism, energy expenditure, and inflammation PPARD is widely expressed in tissues such as the liver, muscle, and adipose tissue, where it helps regulate fatty acid oxidation, glucose metabolism, and mitochondrial function It also plays a key role in regulating the oxidative stress response and modulating the balance between energy storage and energy expenditure PPARD activation has been linked to improvements in insulin sensitivity and lipid profile, making it a potential therapeutic target for metabolic diseases like type 2 diabetes and obesity Additionally, PPARD is involved in the regulation of inflammation and immune responses, and its dysregulation has been implicated in inflammatory diseases, atherosclerosis, and certain cancers Its role in promoting fat burning and mitochondrial function makes PPARD a promising target for the development of therapies aimed at enhancing metabolic health and combating obesity-related conditions
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human, Mouse, Rat
immunogen target
Peroxisome Proliferator Activated Receptor Delta (PPARD)
host
Rabbit
conjugation
Unconjugated
form
Liquid
tested applications
WB, IHC
purification
Purified by affinity chromatography.
buffer
PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
size 1
20 µl
size 2
50 µl
size 3
100 µl
size 4
200 µl
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
PPARD
dry ice
No
availability
Shipped within 5-10 working days.
alias
FAAR,NUC1,NUCI,NR1C2,NUCII,PPARB,Nuclear hormone receptor 1,Nuclear receptor subfamily 1 group C member 2
uniprot id
NCBI accession
NP_803184.1
note
This product is for research use only.
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