Peptidyl-Prolyl Cis-Trans Isomerase NIMA-Interacting 1 (PIN1) Antibody
292.5€ (80 µl)
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Name
Peptidyl-Prolyl Cis-Trans Isomerase NIMA-Interacting 1 (PIN1) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx034932
Tested Applications
ELISA, WB, IHC
Description
Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Peptidyl-Prolyl Cis-Trans Isomerase NIMA-Interacting 1 (PIN1) Immunogen: Purified His-tagged Human PIN1 protein |
| Host | Mouse |
| Reactivity | Human, Mouse, Rat, Monkey |
| Recommended Dilution | WB: 1/1000, IHC-P: 1/25. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Observed MW | Calculated MW: 18.2 kDa |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q13526 |
| NCBI Accession | NP_006212.1 |
| Background | Antibody anti-PIN1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
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