PAXIP1 Antibody (Biotin)
169€ (20 µg)
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935106861
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name
PAXIP1 Antibody (Biotin)
category
Primary Antibodies
provider
Abbexa
reference
abx308100
tested applications
ELISA
Description
PAXIP1 Antibody (Biotin) is a Rabbit Polyclonal against PAXIP1 conjugated to Biotin.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | PAXIP1 |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Biotin |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q6ZW49 |
| Gene ID | 22976 |
| NCBI Accession | NP_031375.3, NM_007349.3, XP_005249596.1, XM_005249539.1 |
| OMIM | 608254 |
| Alias | CAGF28,CAGF29,PACIP1,PAXIP1L,PTIP,TNRC2,PAX transactivation activation domain-interacting protein |
| Background | Antibody anti-PAXIP1 |
| Status | RUO |
Descripción
PAX Interacting Protein 1 (PAXIP1) is a multifunctional nuclear protein that plays a critical role in DNA damage response and repair, particularly through its involvement in homologous recombination repair by recruiting key repair factors to sites of DNA double-strand breaks. It interacts with transcription factor Pax proteins, modulating gene expression essential for embryonic development, cell cycle regulation, and differentiation processes. PAXIP1 is also a core component of histone methyltransferase complexes, where it helps mediate H3K4 methylation, a crucial epigenetic modification linked to transcriptional activation and chromatin structure regulation. Its activity influences diverse biological processes, including immune system development, as it is necessary for effective immunoglobulin class switch recombination in B cells. Aberrations in PAXIP1 expression or function are associated with impaired DNA repair and genomic instability, contributing to tumorigenesis and progression in various cancers. PAXIP1 also serves as a scaffolding protein, facilitating interactions between DNA repair enzymes and chromatin remodelers, ensuring proper response to genotoxic stress. Its regulation is controlled through phosphorylation, enabling dynamic association with chromatin and response proteins, underscoring its role as a pivotal regulator of genome integrity and transcriptional modulation.
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