Paxillin Phospho-Ser272 (PXN pS272) Antibody
221€ (50 µg)
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935106861
info@markelab.com
name
Paxillin Phospho-Ser272 (PXN pS272) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx327103
tested applications
ELISA, WB
Description
PXN (pS272) Antibody is a Rabbit Polyclonal against PXN (pS272).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Paxillin Phospho-Ser272 (PXN pS272) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Data | Modification: Phosphorylation // Target Modification: Ser272 |
| Recommended Dilution | ELISA: 1/10000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P49023 |
| Gene ID | 5829 |
| Alias | PAX,testicular Tissue Protein Li 134 |
| Background | Antibody anti-PXN |
| Status | RUO |
Descripción
Paxillin (PXN) is a focal adhesion-associated adaptor protein that regulates cell adhesion, migration, and cytoskeletal organization by interacting with integrins, growth factor receptors, and signaling proteins at focal adhesions. It contains LIM domains and LD motifs, enabling it to recruit structural and signaling molecules such as focal adhesion kinase (FAK), vinculin, and Src kinases, coordinating actin cytoskeletal dynamics and mechanotransduction. Paxillin is critical for integrin-mediated signaling pathways, linking extracellular matrix (ECM) cues to intracellular processes like cell movement, proliferation, and survival. It plays a key role in embryonic development, tissue remodeling, and wound healing by modulating focal adhesion turnover and actomyosin contractility. Dysregulation of paxillin promotes cancer progression, metastasis, and drug resistance by enhancing cell migration, invasion, and survival signaling. Knockout studies reveal defects in focal adhesion formation, impaired cell motility, and developmental abnormalities, highlighting its essential role in cell adhesion, cytoskeletal regulation, and mechanotransduction.
