Paxillin Phospho-Tyr118 (PXN pY118) Antibody
208€ (20 µl)
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935106861
info@markelab.com
name
Paxillin Phospho-Tyr118 (PXN pY118) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx000208
tested applications
ELISA, WB
Description
PXN (pY118) Antibody is a Rabbit Polyclonal antibody against PXN (pY118). This gene encodes a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. These isoforms exhibit different expression pattern, and have different biochemical, as well as physiological properties (PMID:9054445).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Paxillin Phospho-Tyr118 (PXN pY118) |
| Host | Rabbit |
| Reactivity | Human |
| Assay Data | Modification: Phosphorylation // Target Modification: Tyr118 |
| Recommended Dilution | ELISA: 1 µg/ml, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 20 µl |
| Size 2 | 100 µl |
| Size 3 | 2 × 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P49023 |
| Gene ID | 5829 |
| NCBI Accession | NP_001074324.1 |
| Alias | PAX,testicular Tissue Protein Li 134 |
| Background | Antibody anti-PXN |
| Status | RUO |
| Note | Concentration: > 0.2 mg/ml - |
Descripción
Paxillin (PXN) is a focal adhesion-associated adaptor protein that regulates cell adhesion, migration, and cytoskeletal organization by interacting with integrins, growth factor receptors, and signaling proteins at focal adhesions. It contains LIM domains and LD motifs, enabling it to recruit structural and signaling molecules such as focal adhesion kinase (FAK), vinculin, and Src kinases, coordinating actin cytoskeletal dynamics and mechanotransduction. Paxillin is critical for integrin-mediated signaling pathways, linking extracellular matrix (ECM) cues to intracellular processes like cell movement, proliferation, and survival. It plays a key role in embryonic development, tissue remodeling, and wound healing by modulating focal adhesion turnover and actomyosin contractility. Dysregulation of paxillin promotes cancer progression, metastasis, and drug resistance by enhancing cell migration, invasion, and survival signaling. Knockout studies reveal defects in focal adhesion formation, impaired cell motility, and developmental abnormalities, highlighting its essential role in cell adhesion, cytoskeletal regulation, and mechanotransduction.
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