Paxillin Phospho-Ser178 (PXN pS178) Antibody
429€ (100 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Paxillin Phospho-Ser178 (PXN pS178) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx333342
Tested Applications
ELISA, WB
Description
PXN (pS178) Antibody is a Rabbit Polyclonal against PXN (pS178).
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Paxillin Phospho-Ser178 (PXN pS178) Immunogen: Peptide sequence around phosphorylation site of Serine 178 (A-L-S (p)-P-L) derived from Human Paxillin. |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS (without Mg2+ and Ca2+), pH 7.4, containing 150mM NaCl, 0.02% sodium azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P49023 |
| Alias | PAX,testicular Tissue Protein Li 134 |
| Background | Antibody anti-PXN |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Paxillin (PXN) is a focal adhesion-associated adaptor protein that regulates cell adhesion, migration, and cytoskeletal organization by interacting with integrins, growth factor receptors, and signaling proteins at focal adhesions. It contains LIM domains and LD motifs, enabling it to recruit structural and signaling molecules such as focal adhesion kinase (FAK), vinculin, and Src kinases, coordinating actin cytoskeletal dynamics and mechanotransduction. Paxillin is critical for integrin-mediated signaling pathways, linking extracellular matrix (ECM) cues to intracellular processes like cell movement, proliferation, and survival. It plays a key role in embryonic development, tissue remodeling, and wound healing by modulating focal adhesion turnover and actomyosin contractility. Dysregulation of paxillin promotes cancer progression, metastasis, and drug resistance by enhancing cell migration, invasion, and survival signaling. Knockout studies reveal defects in focal adhesion formation, impaired cell motility, and developmental abnormalities, highlighting its essential role in cell adhesion, cytoskeletal regulation, and mechanotransduction.
Productos relacionados
Paxillin Phospho-Tyr118 (PXN pY118) Antibody
PXN (pY118) Antibody is a Rabbit Polyclonal antibody against PXN (pY118). This gene encodes a cytoskeletal protein invol…
Ver producto
Paxillin (PXN) Antibody
Paxillin (PXN) Antibody is a Rabbit Polyclonal antibody for the detection of PAXI.…
Ver producto
Paxillin (PXN) Antibody
Rabbit polyclonal antibody against Paxillin protein. Immunogen region is Internal. Specificity is as follows for the rea…
Ver producto