Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH1R) Antibody
299€ (50 µl)
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Name
Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH1R) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx402042
Tested Applications
ELISA, WB
Description
Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH1R) Antibody is a Recombinant Rabbit Monoclonal antibody for the detection of Human PTH1R.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH1R) Immunogen: A synthesized peptide derived from human Parathyroid Hormone Receptor 1 |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/500 - 1/5000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Expression | Recombinant |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q03431 |
| Gene ID | 5745 |
| OMIM | 125350 |
| Alias | PTH1R,PPR,PTHR,PTHR1,EKNS, PFE |
| Background | Antibody anti-PTH1R |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
PTH1R is a G protein-coupled receptor activated by parathyroid hormone (PTH) and parathyroid hormone-related peptide (PTHrP). It is primarily expressed in bone, kidney, and cartilage, where it regulates calcium and phosphate homeostasis, bone remodeling, and cartilage development. PTH1R couples to both Gs and Gq proteins, leading to activation of adenylate cyclase (increasing cAMP) and phospholipase C (PLC) pathways. In bone, PTH1R mediates osteoblast activation, enhancing bone formation and resorption in response to PTH. In the kidney, PTH1R regulates calcium reabsorption and phosphate excretion to maintain calcium balance. Dysregulation of PTH1R signaling is associated with hyperparathyroidism, hypoparathyroidism, and bone diseases like osteoporosis. PTH analogs that target PTH1R are used therapeutically to treat osteoporosis and hypoparathyroidism by promoting bone growth and mineral homeostasis. PTH1R’s essential role in calcium regulation and skeletal health makes it a key target for metabolic bone diseases.
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