Parathyroid Hormone Receptor 1 (PTH1R) Antibody (Biotin)
169€ (20 µg)
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Name
Parathyroid Hormone Receptor 1 (PTH1R) Antibody (Biotin)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx336939
Tested Applications
ELISA
Description
PTH1R Antibody (Biotin) is a Rabbit Polyclonal against PTH1R.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Parathyroid Hormone Receptor 1 (PTH1R) Immunogen: Recombinant Human Parathyroid hormone/parathyroid hormone-related peptide receptor protein (485-593AA). |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Biotin |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q03431 |
| Gene ID | 5745 |
| Alias | PTH1R,PPR,PTHR,PTHR1,EKNS, PFE |
| Background | Antibody anti-PTH1R |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
PTH1R is a G protein-coupled receptor activated by parathyroid hormone (PTH) and parathyroid hormone-related peptide (PTHrP). It is primarily expressed in bone, kidney, and cartilage, where it regulates calcium and phosphate homeostasis, bone remodeling, and cartilage development. PTH1R couples to both Gs and Gq proteins, leading to activation of adenylate cyclase (increasing cAMP) and phospholipase C (PLC) pathways. In bone, PTH1R mediates osteoblast activation, enhancing bone formation and resorption in response to PTH. In the kidney, PTH1R regulates calcium reabsorption and phosphate excretion to maintain calcium balance. Dysregulation of PTH1R signaling is associated with hyperparathyroidism, hypoparathyroidism, and bone diseases like osteoporosis. PTH analogs that target PTH1R are used therapeutically to treat osteoporosis and hypoparathyroidism by promoting bone growth and mineral homeostasis. PTH1R’s essential role in calcium regulation and skeletal health makes it a key target for metabolic bone diseases.
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