Parathyroid Hormone Receptor 1 (PTH1R) Antibody
221€ (50 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Parathyroid Hormone Receptor 1 (PTH1R) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx329281
Tested Applications
ELISA, WB, IHC, IF/ICC
Description
PTH1R Antibody is a Rabbit Polyclonal against PTH1R.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Parathyroid Hormone Receptor 1 (PTH1R) Immunogen: Synthesized peptide derived from the Internal region of human PTH/PTHrP-R. |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/300, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Buffer | PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q03431 |
| Gene ID | 5745 |
| Alias | PTH1R,PPR,PTHR,PTHR1,EKNS, PFE |
| Background | Antibody anti-PTH1R |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
PTH1R is a G protein-coupled receptor activated by parathyroid hormone (PTH) and parathyroid hormone-related peptide (PTHrP). It is primarily expressed in bone, kidney, and cartilage, where it regulates calcium and phosphate homeostasis, bone remodeling, and cartilage development. PTH1R couples to both Gs and Gq proteins, leading to activation of adenylate cyclase (increasing cAMP) and phospholipase C (PLC) pathways. In bone, PTH1R mediates osteoblast activation, enhancing bone formation and resorption in response to PTH. In the kidney, PTH1R regulates calcium reabsorption and phosphate excretion to maintain calcium balance. Dysregulation of PTH1R signaling is associated with hyperparathyroidism, hypoparathyroidism, and bone diseases like osteoporosis. PTH analogs that target PTH1R are used therapeutically to treat osteoporosis and hypoparathyroidism by promoting bone growth and mineral homeostasis. PTH1R’s essential role in calcium regulation and skeletal health makes it a key target for metabolic bone diseases.
Productos relacionados
Parathyroid Hormone Receptor 1 (PTH1R) Antibody
PTH1R Antibody is a Rabbit Polyclonal antibody against PTH1R. The protein encoded by this gene is a member of the G-prot…
Ver producto
Parathyroid Hormone Receptor 1 (PTH1R) Antibody
The protein encoded by this gene is a member of the G-protein coupled receptor family 2. This protein is a receptor for …
Ver producto
Human Parathyroid Hormone Receptor 1 (PTH1R) ELISA Kit
Human Parathyroid Hormone Receptor 1 (PTH1R) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Huma…
Ver producto