Parathyroid Hormone 2 Receptor (PTH2R) Antibody
169€ (20 µg)
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Name
Parathyroid Hormone 2 Receptor (PTH2R) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx110696
Tested Applications
ELISA, IF/ICC
Description
Parathyroid hormone 2 receptor Antibody is a Rabbit Polyclonal antibody against Parathyroid hormone 2 receptor.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Parathyroid Hormone 2 Receptor (PTH2R) Immunogen: Recombinant human Parathyroid hormone 2 receptor protein (27-145AA). |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P49190 |
| Gene ID | 5746 |
| OMIM | 601469 |
| Alias | PTH2R,PTHR2 |
| Background | Antibody anti-PTH2R |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
PTH2R is a G protein-coupled receptor activated primarily by tuberoinfundibular peptide of 39 residues (TIP39) and, to a lesser extent, parathyroid hormone (PTH). Unlike PTH1R, PTH2R is not involved in calcium homeostasis but instead regulates neuroendocrine functions, pain signaling, and vasodilation. PTH2R is predominantly expressed in the central nervous system, including the hypothalamus and brainstem, as well as in pancreatic and cardiovascular tissues. It couples to Gs proteins, stimulating adenylate cyclase and increasing intracellular cAMP levels. PTH2R modulates neuropeptide release, pain perception, and stress responses. Emerging evidence suggests its involvement in regulating hypothalamic-pituitary functions and modulating blood flow. Dysregulation of PTH2R signaling is linked to altered pain sensitivity, stress-related disorders, and neuroendocrine dysfunction. Targeting PTH2R has therapeutic potential for managing chronic pain, stress disorders, and cardiovascular regulation, highlighting its role in neuropeptide-mediated signaling.
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