Par-3 Partitioning Defective 3 Homolog (PARD3) Antibody

Background

PARD3 is a polarity protein essential for establishing and maintaining cell polarity during processes like epithelial tissue organization, asymmetric cell division, and neuronal development. It is a component of the Par complex, which includes PARD6 and atypical protein kinase C (aPKC), and regulates apical-basal polarity by interacting with tight junction components and cytoskeletal regulators. PARD3 is critical for tight junction formation, cell adhesion, and actin cytoskeleton organization in epithelial and endothelial cells. It is highly expressed in polarized tissues and neurons, where it regulates axon specification, neuronal migration, and synaptic organization. Dysregulation of PARD3 contributes to cancer progression, particularly in epithelial tumors, by disrupting cell polarity, adhesion, and promoting metastasis. PARD3 also plays roles in stem cell self-renewal, tissue homeostasis, and endothelial barrier function. Knockout studies reveal defects in tissue architecture, impaired cell polarization, and embryonic lethality, emphasizing its fundamental role in polarity establishment and tissue integrity.