Par-3 Partitioning Defective 3 Homolog (PARD3) Antibody
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
Rabbit polyclonal antibody against PARD3 protein. Immunogen region is C-terminal.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Par-3 Partitioning Defective 3 Homolog (PARD3) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/3000, IF/ICC: 1/100 - 1/500, ELISA: 1/20000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IF/ICC |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8TEW0 |
| Alias | PARD3, ASIP, Baz, PAR3, PAR3alpha, PARD-3, PARD3A, PPP1R118, SE2-5L16, SE2-5LT1, SE2-5T2, par-3 family cell polarity regulator |
| Background | Antibody anti-PARD3 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
PARD3 is a polarity protein essential for establishing and maintaining cell polarity during processes like epithelial tissue organization, asymmetric cell division, and neuronal development. It is a component of the Par complex, which includes PARD6 and atypical protein kinase C (aPKC), and regulates apical-basal polarity by interacting with tight junction components and cytoskeletal regulators. PARD3 is critical for tight junction formation, cell adhesion, and actin cytoskeleton organization in epithelial and endothelial cells. It is highly expressed in polarized tissues and neurons, where it regulates axon specification, neuronal migration, and synaptic organization. Dysregulation of PARD3 contributes to cancer progression, particularly in epithelial tumors, by disrupting cell polarity, adhesion, and promoting metastasis. PARD3 also plays roles in stem cell self-renewal, tissue homeostasis, and endothelial barrier function. Knockout studies reveal defects in tissue architecture, impaired cell polarization, and embryonic lethality, emphasizing its fundamental role in polarity establishment and tissue integrity.
Related Products
anti- PARD3 antibody
Adapter protein involved in asymmetrical cell division and cell polarization processes. Seems to play a central role in the formation of epithelial tight junctions. Targets the phosphatase PTEN to cell junctions. Involved in Schwann cell peripheral myelination(By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons.PARD3 has three splice isoforms at 100 kDa, 150 kDa, and 180 kDa. This polyclonal antibody raised against C-terminal 281 amino acids of human PARD3 recognizes these three isoforms.
Ver Producto
Recombinant Human PARD3
Ver Producto
Par-3 Partitioning Defective 3 Homolog (PARD3) Antibody
Rabbit polyclonal antibody against PARD3 protein. Immunogen region is C-terminal.
Ver Producto