Paired Box Protein Pax-6 (PAX6) Antibody
416€ (200 µl)
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935106861
info@markelab.com
name
Paired Box Protein Pax-6 (PAX6) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx431493
tested applications
P-ELISA, WB
Description
PAX6 Antibody is a Goat Polyclonal antibody against PAX6.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Paired Box Protein Pax-6 (PAX6) |
| Host | Goat |
| Reactivity | Mouse |
| Recommended Dilution | P-ELISA: 1/32000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 5080, 18508, 25509 |
| NCBI Accession | NP_000271.1, NP_001595.2 |
| Alias | AN,AN1,AN2,ASGD5,D11S812E,FVH1,MGDA,WAGR,Aniridia type II protein,Oculorhombin |
| Background | Antibody anti-PAX6 |
| Status | RUO |
| Note | Concentration: 0.5 mg/ml - |
Descripción
PAX6 is a highly conserved transcription factor critical for the development of the eyes, central nervous system, and endocrine pancreas. It regulates the expression of genes involved in eye morphogenesis, lens formation, and neuronal differentiation. PAX6 acts as a master regulator of ocular development, with its mutations causing congenital eye disorders such as aniridia, Peters anomaly, and microphthalmia. It also plays a role in brain patterning, where it contributes to neurogenesis and cortical layer formation. PAX6 is essential for pancreatic β-cell development, where it influences insulin production and glucose regulation. Dysregulation of PAX6 has been linked to neurological disorders and metabolic dysfunction. Knockout studies in mice reveal severe ocular malformations, brain developmental defects, and pancreatic abnormalities, highlighting its critical role in tissue differentiation, organogenesis, and cell fate determination during embryonic development.
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