Paired Box Protein Pax-4 (PAX4) Antibody
364€ (100 µg)
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935106861
info@markelab.com
name
Paired Box Protein Pax-4 (PAX4) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx240028
tested applications
ELISA, IHC
Description
Paired Box Protein Pax-4 (PAX4) Antibody is a Rabbit Polyclonal antibody for the detection of PAX4.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Paired Box Protein Pax-4 (PAX4) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | IHC: 1/50 - 1/500. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O43316 |
| Alias | KPD, MODY9 |
| Background | Antibody anti-PAX4 |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
PAX4 is a transcription factor involved in the development and differentiation of pancreatic β-cells, essential for insulin production. PAX4 plays a critical role during embryonic development by repressing the α-cell lineage and promoting the specification of endocrine progenitor cells into β-cells within the pancreas. It directly regulates genes involved in β-cell identity, proliferation, and survival. Mutations in PAX4 are associated with monogenic forms of diabetes, such as maturity-onset diabetes of the young (MODY) and other metabolic disorders due to insufficient insulin production. PAX4 expression is tightly regulated, and its overexpression can influence β-cell regeneration, offering therapeutic potential for diabetes treatment. Knockout models show impaired β-cell development, hyperglycemia, and defective glucose homeostasis, underscoring PAX4's pivotal role in pancreatic endocrine development, insulin regulation, and diabetes pathology.
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