Paired Box Protein Pax-4 (PAX4) Antibody
383.5€ (100 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Paired Box Protein Pax-4 (PAX4) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx012179
Tested Applications
ELISA
Description
This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The paired box 4 gene is involved in pancreatic islet development and mouse studies have demonstrated a role for this gene in differentiation of insulin-producing beta cells.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Paired Box Protein Pax-4 (PAX4) Immunogen: Purified recombinant fragment of human PAX4 expressed in E. coli. |
| Host | Mouse |
| Reactivity | Human |
| Assay Type | Concentration: Not determined. |
| Recommended Dilution | ELISA: 1/10000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Observed MW | 38 kDa |
| Purification | Unpurified ascites. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O43316 |
| Gene ID | 5078 |
| OMIM | 125853 |
| Alias | KPD, MODY9 |
| Background | Antibody anti-PAX4 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
PAX4 is a transcription factor involved in the development and differentiation of pancreatic β-cells, essential for insulin production. PAX4 plays a critical role during embryonic development by repressing the α-cell lineage and promoting the specification of endocrine progenitor cells into β-cells within the pancreas. It directly regulates genes involved in β-cell identity, proliferation, and survival. Mutations in PAX4 are associated with monogenic forms of diabetes, such as maturity-onset diabetes of the young (MODY) and other metabolic disorders due to insufficient insulin production. PAX4 expression is tightly regulated, and its overexpression can influence β-cell regeneration, offering therapeutic potential for diabetes treatment. Knockout models show impaired β-cell development, hyperglycemia, and defective glucose homeostasis, underscoring PAX4's pivotal role in pancreatic endocrine development, insulin regulation, and diabetes pathology.
Productos relacionados
Paired Box Protein Pax-4 (PAX4) Antibody
PAX4 Antibody is a Rabbit Polyclonal Antibody against PAX4.…
Ver producto Paired Box Protein Pax-4 (PAX4) Antibody
This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically con…
Ver producto
Paired Box Protein Pax-4 (PAX4) Antibody
PAX4 is a member of the paired box (PAX) family of transcription factors. These proteins play critical roles during feta…
Ver producto