Paired Box 3 (PAX3) Antibody
383.5€ (100 µl)
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Name
Paired Box 3 (PAX3) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx015952
Tested Applications
ELISA, WB
Description
This gene is a member of the paired box (PAX) family of transcription factors.Members of the PAX family typically contain a paired box domain and a paired-type homeodomain.These genes play critical roles during fetal development.Mutations in paired box gene 3 are associated with Waardenburg syndrome, craniofacial-deafness-hand syndrome, and alveolar rhabdomyosarcoma.The translocation t (2;13) (q35;q14), which represents a fusion between PAX3 and the forkhead gene, is a frequent finding in alveolar rhabdomyosarcoma.Alternative splicing results in transcripts encoding isoforms with different C-termini.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Paired Box 3 (PAX3) Immunogen: Purified recombinant fragment of human PAX3 (AA: 142-203) expressed in E. coli. |
| Host | Mouse |
| Reactivity | Human, Mouse |
| Assay Type | Concentration: Not determined. |
| Recommended Dilution | ELISA: 1/10000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Observed MW | 53 kDa |
| Purification | Unpurified ascites. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 5077 |
| Alias | CDHS,HUP2,PAX-3,WS1,WS3 |
| Background | Antibody anti-PAX3 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
PAX3 is a transcription factor belonging to the paired box (PAX) family, essential for embryonic development, particularly in neural crest cell migration, muscle formation, and melanocyte differentiation. PAX3 regulates genes involved in cell survival, proliferation, and lineage determination during development of the neural tube, skeletal muscles, and craniofacial structures. Mutations in PAX3 are associated with Waardenburg syndrome types I and III, characterized by hearing loss, pigmentation abnormalities, and skeletal defects due to impaired neural crest development. PAX3 also plays a role in myogenesis by activating MyoD and other myogenic regulatory factors. In cancers like alveolar rhabdomyosarcoma, chromosomal translocations involving PAX3 result in oncogenic fusion proteins (e.g., PAX3-FOXO1) that drive tumorigenesis by promoting unchecked proliferation and inhibiting differentiation. Knockout models show defects in neural crest migration, craniofacial anomalies, and muscle development failures, emphasizing PAX3's role in embryonic tissue patterning and organogenesis.
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