Orexin/Hypocretin receptor type 1 (HCRTR1) Antibody (HRP)

Este producto es parte de HCRTR - Orexin Receptor Type
Product Graph
260€ (50 µl)

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.

935106861
info@markelab.com
name
Orexin/Hypocretin receptor type 1 (HCRTR1) Antibody (HRP)
category
Primary Antibodies
provider
Abbexa
reference
abx343090
tested applications
ELISA

Description

Orexin/Hypocretin receptor type 1 (HCRTR1) Antibody (HRP) is a Rabbit Polyclonal antibody conjugated to HRP for the detection of Human HCRTR1.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Orexin/Hypocretin receptor type 1 (HCRTR1)
Host
Rabbit
Reactivity
Human
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
HRP
Isotype
IgG
Purity
> 95%
Purification
Purified by Protein G chromatography.
Size 1
50 µl
Size 2
100 µl
Size 3
200 µl
Size 4
1 ml
Form
Liquid
Tested Applications
ELISA
Buffer
0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% glycerol.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
O43613
Alias
HCRTR1,Hctr1,hypocretin receptor 1,orexin receptor type 1,OX1R,OX1R,OXR1,ORXR1
Background
Antibody anti-HCRTR1
Status
RUO

Descripción

HCRTR1 is a G protein-coupled receptor that binds orexin-A, a neuropeptide involved in wakefulness, arousal, and feeding regulation. HCRTR1 is predominantly expressed in the hypothalamus, locus coeruleus, and other brain regions involved in the sleep-wake cycle, reward pathways, and energy homeostasis. It couples primarily to Gq proteins, activating phospholipase C (PLC), increasing intracellular calcium, and stimulating downstream signaling pathways such as MAPK. HCRTR1 plays a central role in maintaining wakefulness, promoting arousal, and modulating motivation and reward-seeking behavior. Dysregulation of HCRTR1 is associated with sleep disorders like narcolepsy, characterized by excessive daytime sleepiness and cataplexy, as well as addiction and obesity. Selective HCRTR1 antagonists are being developed to treat insomnia by promoting sleep onset, while agonists are explored for narcolepsy and other disorders of arousal. Its role in wakefulness, reward processing, and energy regulation makes HCRTR1 a critical therapeutic target for sleep, mood, and metabolic disorders.

Related Products

EH1102

Human HCRTR1 (Orexin receptor type 1) ELISA Kit

Ver Producto
FNab06010

HCRTR1 antibody

Ver Producto
P2079

Recombinant Human HCRTR1

Ver Producto