Human HCRTR1 (Orexin receptor type 1) ELISA Kit
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name
Human HCRTR1 (Orexin receptor type 1) ELISA Kit
category
ELISA Kits
provider
FineTest
reference
EH1102
tested applications
ELISA
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | 4 hours |
| Assay Type | Sandwich ELISA, Double Antibody |
| Test Range | 78.125-5000pg/ml |
| Sensitivity | 46.875pg/ml |
| Size 1 | 96T |
| Tested Applications | ELISA |
| Sample Type | Serum, Plasma, Cell Culture Supernatant, cell or tissue lysate, Other liquid samples |
| Availability | Shipped within 10-14 working days. |
| Storage | 2-8 °C for 12 months |
| UniProt ID | O43613 |
| Alias | HCRTR1,Hctr1,hypocretin receptor 1,orexin receptor type 1,OX1R,OX1R,OXR1,ORXR1 |
| Background | Elisa kits for HCRTR1 |
| Status | RUO |
HCRTR1 is a G protein-coupled receptor that binds orexin-A, a neuropeptide involved in wakefulness, arousal, and feeding regulation. HCRTR1 is predominantly expressed in the hypothalamus, locus coeruleus, and other brain regions involved in the sleep-wake cycle, reward pathways, and energy homeostasis. It couples primarily to Gq proteins, activating phospholipase C (PLC), increasing intracellular calcium, and stimulating downstream signaling pathways such as MAPK. HCRTR1 plays a central role in maintaining wakefulness, promoting arousal, and modulating motivation and reward-seeking behavior. Dysregulation of HCRTR1 is associated with sleep disorders like narcolepsy, characterized by excessive daytime sleepiness and cataplexy, as well as addiction and obesity. Selective HCRTR1 antagonists are being developed to treat insomnia by promoting sleep onset, while agonists are explored for narcolepsy and other disorders of arousal. Its role in wakefulness, reward processing, and energy regulation makes HCRTR1 a critical therapeutic target for sleep, mood, and metabolic disorders.
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