Orexin Receptor Type 1 (HCRTR1) Antibody
52€ (10 µg)
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935106861
info@markelab.com
name
Orexin Receptor Type 1 (HCRTR1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx015529
tested applications
ELISA, WB
Description
Rabbit polyclonal antibody against HCRTR1 protein. Immunogen region is Internal.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Orexin Receptor Type 1 (HCRTR1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/3000, ELISA: 1/5000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O43613 |
| Alias | HCRTR1,Hctr1,hypocretin receptor 1,orexin receptor type 1,OX1R,OX1R,OXR1,ORXR1 |
| Background | Antibody anti-HCRTR1 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
HCRTR1 is a G protein-coupled receptor that binds orexin-A, a neuropeptide involved in wakefulness, arousal, and feeding regulation. HCRTR1 is predominantly expressed in the hypothalamus, locus coeruleus, and other brain regions involved in the sleep-wake cycle, reward pathways, and energy homeostasis. It couples primarily to Gq proteins, activating phospholipase C (PLC), increasing intracellular calcium, and stimulating downstream signaling pathways such as MAPK. HCRTR1 plays a central role in maintaining wakefulness, promoting arousal, and modulating motivation and reward-seeking behavior. Dysregulation of HCRTR1 is associated with sleep disorders like narcolepsy, characterized by excessive daytime sleepiness and cataplexy, as well as addiction and obesity. Selective HCRTR1 antagonists are being developed to treat insomnia by promoting sleep onset, while agonists are explored for narcolepsy and other disorders of arousal. Its role in wakefulness, reward processing, and energy regulation makes HCRTR1 a critical therapeutic target for sleep, mood, and metabolic disorders.
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