Opioid Receptor Kappa 1 (OPRK1) Antibody
442€ (200 µl)
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935106861
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name
Opioid Receptor Kappa 1 (OPRK1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx431478
tested applications
P-ELISA, WB
Description
OPRK1 Antibody is a Goat Polyclonal antibody against OPRK1.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Opioid Receptor Kappa 1 (OPRK1) Immunogen: abx616455 - C-Terminus: C-PAYLRDIDGMNKP |
| Host | Goat |
| Reactivity | Human |
| Assay Type | Concentration: 0.5 mg/ml |
| Recommended Dilution | P-ELISA: 1/16000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 4986, 18387, 29335 |
| NCBI Accession | NP_000903.2 |
| Alias | OPRK1,KOR-1,Kappa receptor,OP2,KOP,KOPr,OPRK, K-OR-1 |
| Background | Antibody anti-OPRK1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
OPRK1, or the kappa-opioid receptor, is a G protein-coupled receptor (GPCR) that binds endogenous opioid peptides such as dynorphins. It is widely expressed in the central nervous system, particularly in regions like the spinal cord, hypothalamus, and limbic system, where it modulates pain, stress responses, and mood. OPRK1 couples to Gi/o proteins, leading to inhibition of adenylate cyclase, decreased cAMP production, and reduced neurotransmitter release. Activation of OPRK1 produces analgesia, particularly in visceral and spinal pain pathways, and induces dysphoria and sedation. OPRK1 also plays a key role in stress-induced behaviors, drug addiction, and depression, where its activation can reduce dopamine release and inhibit reward pathways. Dysregulation of OPRK1 signaling contributes to chronic pain, addiction, and stress-related disorders. Kappa-opioid receptor agonists are being developed as non-addictive analgesics, while antagonists are under investigation for treating mood disorders, addiction, and stress resilience, positioning OPRK1 as a dual therapeutic target.
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