Nucleosome-Remodeling Factor Subunit BPTF (BPTF) Antibody
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Description
Nucleosome-Remodeling Factor Subunit BPTF (BPTF) Antibody is a Rabbit Polyclonal antibody against Nucleosome-Remodeling Factor Subunit BPTF (BPTF).
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Nucleosome-Remodeling Factor Subunit BPTF (BPTF) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Validated in IHC-P and IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Buffer | PBS, pH 7.4, containing 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q12830 |
| Background | Antibody anti-BPTF |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
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Recombinant Human BPTF
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Nucleosome-Remodeling Factor Subunit BPTF (BPTF) Antibody
BPTF (bromodomain and PHD domain transcription factor) is the largest subunit of the ATP-dependent chromatin-remodelling complex, NURF (nucleosome remodelling factor). NURF catalyses ATP-dependent nucleosome sliding and facilitates transcription. BPTF recognises histone H3 tails that are tri-methylated at K4, which marks the transcriptional start site of the vast majority of transcriptionally active genes. BPTF also exhibits some binding to H3 di-methylated at K4. BPTF plays a key role in the development of early mouse embryos, possibly through regulation of the Smad pathway of transcription factors. While BPTF is expressed in low levels in the adult brain and spinal cord, it is expressed in higher levels in the brain in neurodegenerative diseases. It is present in a subset of amyloid-containing plaques in the brains of patients suffering from Alzheimer's disease. Abundantly expressed in the fetal brain. Present throughout the gray and white matter of the developing spinal cord at 18-22 gestational weeks. Expressed at low levels in adult brain and spinal cord and reexpressed in neurodegenerative diseases (at protein level).Tissue specificity: Ubiquitously expressed, with highest levels in testis. Present in kidney, liver and brain. In the brain, highest levels are found in motor cortex (at protein level).
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Nucleosome-Remodeling Factor Subunit BPTF (BPTF) Antibody
Nucleosome-Remodeling Factor Subunit BPTF (BPTF) Antibody is a Rabbit Polyclonal antibody against Nucleosome-Remodeling Factor Subunit BPTF (BPTF).
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