Nucleosome Assembly Protein 1-Like 2 (NAP1L2) Antibody

Background

Nucleosome assembly protein 1 like 2 (NAP1L2) is a chromatin-remodeling protein that plays a crucial role in the assembly and disassembly of nucleosomes, the basic structural units of chromatin NAP1L2 is involved in the regulation of gene expression by facilitating the proper packaging of DNA into nucleosomes while allowing access to the genetic material for transcription, replication, and repair The protein aids in the dynamic regulation of chromatin structure, influencing DNA accessibility and the function of transcription factors, histone-modifying enzymes, and other chromatin-associated proteins NAP1L2’s role in maintaining chromatin homeostasis is essential for normal cell function, particularly during cell cycle progression, DNA repair, and cellular differentiation Dysregulation of NAP1L2 expression or function is associated with genomic instability and cancer, where abnormal chromatin assembly can lead to defective gene expression and uncontrolled cell proliferation NAP1L2’s involvement in DNA damage response pathways underscores its importance in maintaining cellular integrity and preventing diseases such as cancer and developmental disorders