Nucleoporin NUP42 / NUPL2 (NUP42) Antibody (FITC)
169€ (20 µg)
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935106861
info@markelab.com
name
Nucleoporin NUP42 / NUPL2 (NUP42) Antibody (FITC)
category
Primary Antibodies
provider
Abbexa
reference
abx304686
Description
NUP42 Antibody (FITC) is a Rabbit Polyclonal against NUP42 conjugated to FITC.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Nucleoporin NUP42 / NUPL2 (NUP42) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | FITC |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O15504 |
| Gene ID | 11097 |
| NCBI Accession | NP_031368.1, NM_007342.2 |
| Alias | CG1,NLP1,UIP1,Hcg1,NLP-1,NLP_1,NUPL2,Nucleoporin-like protein 2, nucleoporin-like protein 1 |
| Background | Antibody anti-NUP42 |
| Status | RUO |
Descripción
Nucleoporin 42 (NUP42), also known as NupL1, is a component of the nuclear pore complex (NPC), which regulates the bidirectional transport of macromolecules such as RNA and proteins between the nucleus and cytoplasm. NUP42 is specifically associated with the cytoplasmic face of the NPC and plays a critical role in mRNA export and other transport pathways. It interacts with the CRM1 export receptor, facilitating the export of certain cargoes during cellular stress responses and viral infections. Mutations or dysregulation of NUP42 can affect nucleocytoplasmic transport, contributing to cellular senescence, developmental defects, and diseases such as cancer and neurodegenerative disorders. Understanding its function provides insights into the dynamics of nuclear-cytoplasmic communication and the mechanisms underlying related pathologies.
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