Nucleoporin NUP42 / NUPL2 (NUP42) Antibody
312€ (60 µl)
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Name
Nucleoporin NUP42 / NUPL2 (NUP42) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx126287
Tested Applications
WB
Description
NUP42 Antibody is a Rabbit Polyclonal against NUP42.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Nucleoporin NUP42 / NUPL2 (NUP42) Immunogen: Recombinant fusion protein corresponding to human NUPL2 |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 19 kDa/25 kDa/44 kDa Observed MW: 45 kDa |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | WB |
| Buffer | PBS, pH 7.3, containing 0.01% thiomersal, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O15504 |
| Gene ID | 11097 |
| NCBI Accession | NP_031368.1 |
| Alias | CG1,NLP1,UIP1,Hcg1,NLP-1,NLP_1,NUPL2,Nucleoporin-like protein 2, nucleoporin-like protein 1 |
| Background | Antibody anti-NUP42 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Nucleoporin 42 (NUP42), also known as NupL1, is a component of the nuclear pore complex (NPC), which regulates the bidirectional transport of macromolecules such as RNA and proteins between the nucleus and cytoplasm. NUP42 is specifically associated with the cytoplasmic face of the NPC and plays a critical role in mRNA export and other transport pathways. It interacts with the CRM1 export receptor, facilitating the export of certain cargoes during cellular stress responses and viral infections. Mutations or dysregulation of NUP42 can affect nucleocytoplasmic transport, contributing to cellular senescence, developmental defects, and diseases such as cancer and neurodegenerative disorders. Understanding its function provides insights into the dynamics of nuclear-cytoplasmic communication and the mechanisms underlying related pathologies.