Nucleoporin 88 kDa (NUP88) Antibody

Background

Nucleoporin 88 (NUP88) is a component of the nuclear pore complex that plays a crucial role in regulating nucleocytoplasmic transport, particularly in the selective exchange of proteins, RNA, and other macromolecules between the nucleus and cytoplasm NUP88 contributes to the structural integrity of the nuclear pore and the transport processes that occur through it It is involved in facilitating the export of RNA from the nucleus and the import of various proteins that are essential for cellular functions such as gene expression, cell cycle regulation, and DNA repair NUP88 also interacts with other nucleoporins to form a part of the nuclear pore's central channel, which is critical for maintaining proper cellular function Studies have linked dysregulation of NUP88 to several diseases, particularly cancers, where its overexpression can promote tumor cell survival, metastasis, and resistance to chemotherapy Additionally, mutations in NUP88 are associated with altered protein trafficking and gene expression regulation, contributing to the pathogenesis of various disorders