Nucleoporin 62 (NUP62) Antibody
292.5€ (80 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Nucleoporin 62 (NUP62) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx033433
Tested Applications
ELISA, WB, IHC, FCM
Description
NUP62 is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. This protein is a member of the FG-repeat containing nucleoporins and is localized to the nuclear pore central plug. The protein associates with the importin alpha/beta complex which is involved in the import of proteins containing nuclear localization signals.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Nucleoporin 62 (NUP62) Immunogen: KLH-conjugated synthetic peptide between 492-520 amino acids from the C-terminal region of human NUP62. |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000, IHC-P: 1/50 - 1/100, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 53.3 kDa |
| Purification | Purified Rabbit Polyclonal Antibody. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, FCM |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P37198 |
| Alias | p62,IBSN,SNDI,nuclear pore glycoprotein p62,Nucleoporin Nup62 |
| Background | Antibody anti-NUP62 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Nucleoporin 62 (NUP62) is an essential member of the nuclear pore complex, playing a pivotal role in the selective transport of macromolecules across the nuclear envelope It facilitates the movement of RNA, proteins, and other molecules between the nucleus and cytoplasm, contributing to essential processes such as transcription, DNA replication, and cell cycle regulation NUP62 works in tandem with other nucleoporins to form the nuclear pore, allowing for controlled molecular trafficking essential for maintaining cellular function It interacts with various transport factors to regulate the export of RNA and ribosomal subunits to the cytoplasm, a key step in protein synthesis Dysregulation of NUP62 has been linked to numerous diseases, including cancers, where disruptions in nucleocytoplasmic transport lead to mislocalization of critical regulatory proteins, contributing to uncontrolled cell growth and survival Additionally, NUP62 is involved in cellular stress responses and repair mechanisms, emphasizing its role in tissue homeostasis and cell survival under adverse conditions The importance of NUP62 in gene regulation, protein synthesis, and cellular stress management highlights its central role in maintaining proper cellular function and tissue integrity
Productos relacionados
Nucleoporin 62 (NUP62) Antibody
NUP62 Antibody is a Rabbit Polyclonal antibody against NUP62. The nuclear pore complex is a massive structure that exten…
Ver producto Nucleoporin 62 (NUP62) Antibody
NUP62 is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macr…
Ver producto
Nucleoporin 62 kDa (NUP62) Antibody
Nucleoporin 62 kDa Antibody is a Rabbit Polyclonal antibody against Nucleoporin 62 kDa.…
Ver producto