Nucleoporin 153 kDa (NUP153) Antibody

Product specifications

Primary Antibodies

Nucleoporin 153 kDa (NUP153)

Rabbit

Human, Mouse, Rat

Optimal dilutions/concentrations should be determined by the end user.

Polyclonal

Unconjugated

IgG

Antigen Affinity Chromatography.

100 µl

Liquid

ELISA, WB

PBS, pH 7.3, containing 0.02% Sodium Azide and 50% Glycerol.

Shipped within 5-10 working days.

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

No

P49790

9972

NP_001265138.1, NM_001278209.1, NP_001265139.1, NM_001278210.1, NP_005115.2, NM_005124.3

603948

N153,HNUP153,nucleoporin 153kDa,Nuclear pore complex protein Nup153

Antibody anti-NUP153

RUO

Descripción

Nucleoporin 153 (NUP153) is an essential component of the nuclear pore complex (NPC) that plays a significant role in nucleocytoplasmic transport NUP153 is involved in the structural maintenance of the NPC and aids in the selective trafficking of proteins, RNA, and ribosomal subunits across the nuclear envelope It functions as an anchor point for other nucleoporins, stabilizing the nuclear pore structure and facilitating the proper exchange of molecules between the nucleus and cytoplasm NUP153 also participates in the regulation of gene expression, ensuring the efficient export of mRNA from the nucleus to the cytoplasm for translation During cell division, NUP153 helps maintain nuclear envelope integrity, ensuring proper nuclear compartmentalization and cell cycle progression Dysregulation of NUP153 has been linked to various diseases, including cancers and neurodegenerative disorders, where faulty nuclear transport can disrupt cellular processes, leading to genomic instability and abnormal cell proliferation

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NUP153 antibody

Component of the nuclear pore complex(NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element(CTE) in a NXF1-and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex(NPC).

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Nucleoporin 153 (NUP153) Antibody

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