Nucleoporin 133 kDa (NUP133) Antibody

Background

Nucleoporin 133 (NUP133) is a nucleoporin involved in the nuclear pore complex, which regulates the selective transport of molecules between the nucleus and cytoplasm NUP133 is essential for the structural integrity of the nuclear pore and is involved in the formation of the central channel that facilitates the trafficking of RNA, proteins, and ribosomal subunits NUP133 plays a critical role in ensuring efficient gene expression by allowing the proper export of mRNA from the nucleus to the cytoplasm for translation Dysregulation of NUP133 has been associated with cellular processes such as the cell cycle, DNA repair, and immune responses It is particularly important for maintaining nuclear function during cell division and ensuring the proper functioning of mitosis NUP133 has also been implicated in cancer, where alterations in nucleocytoplasmic transport contribute to abnormal gene expression and tumor progression Its role in regulating cell cycle checkpoints and maintaining genomic stability makes NUP133 crucial for proper cell function and tissue homeostasis