Nuclear Receptor Subfamily 3, Group C, Member 1 Phospho-Ser211 (NR3C1 pS211) Antibody
221€ (50 µg)
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Name
Nuclear Receptor Subfamily 3, Group C, Member 1 Phospho-Ser211 (NR3C1 pS211) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx328985
Tested Applications
ELISA, WB, IHC
Description
NR3C1 (pS211) Antibody is a Rabbit Polyclonal against NR3C1 (pS211).
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Nuclear Receptor Subfamily 3, Group C, Member 1 Phospho-Ser211 (NR3C1 pS211) Immunogen: Synthesized peptide derived from human GR around the phosphorylation site of S211. |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | ELISA: 1/5000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/300. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P04150 |
| Gene ID | 2908 |
| Alias | GR,GCR,GRL,GCCR,GCRST,Glucocorticoid receptor |
| Background | Antibody anti-NR3C1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Nuclear receptor subfamily 3 group C member 1 (NR3C1), also known as the glucocorticoid receptor (GR), is a nuclear receptor that mediates the effects of glucocorticoids, hormones involved in stress response, metabolism, and immune function NR3C1 is activated by glucocorticoids, such as cortisol, and regulates the expression of genes involved in inflammation, immune suppression, and metabolism It is expressed in a variety of tissues, including the liver, immune cells, and brain, where it influences processes such as glucose metabolism, fat storage, and the immune response NR3C1 plays a key role in the body’s response to stress by regulating the hypothalamic-pituitary-adrenal (HPA) axis, which controls the production of cortisol and other stress hormones Dysregulation of NR3C1 signaling has been linked to various diseases, including metabolic syndrome, depression, autoimmune disorders, and cancer, where improper glucocorticoid signaling can contribute to inflammation, altered metabolism, and immune dysfunction GR is also a target for corticosteroid drugs used to treat conditions like asthma, arthritis, and autoimmune diseases
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