Nuclear Receptor Subfamily 2 Group E Member 1 (NR2E1) Antibody
169€ (20 µl)
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Name
Nuclear Receptor Subfamily 2 Group E Member 1 (NR2E1) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx322430
Tested Applications
ELISA, WB, IHC
Description
NR2E1 Antibody is a Rabbit Polyclonal against NR2E1.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Nuclear Receptor Subfamily 2 Group E Member 1 (NR2E1) Immunogen: Recombinant human Nuclear receptor subfamily 2 group E member 1 protein (106-385AA). |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1/1000 - 1/5000, IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 20 µl |
| Size 2 | 50 µl |
| Size 3 | 100 µl |
| Size 4 | 200 µl |
| Size 5 | 1 ml |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9Y466 |
| Gene ID | 7101 |
| NCBI Accession | NP_001273031.1, NM_001286102.1, NP_003260.1, NM_003269.4 |
| OMIM | 603849 |
| Alias | TLL,TLX,XTLL,Nuclear receptor TLX,Protein tailless homolog (Tll; hTll) |
| Background | Antibody anti-NR2E1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Nuclear receptor subfamily 2 group E member 1 (NR2E1), also known as TLX, is a nuclear receptor that plays a critical role in regulating the development and function of the central nervous system NR2E1 is primarily expressed in the brain, where it controls the differentiation, proliferation, and maintenance of neural stem cells It regulates neurogenesis during development and also helps maintain neural stem cells in the adult brain, allowing for plasticity and repair after injury NR2E1 modulates the expression of genes involved in the maintenance of neural stem cell populations and the formation of new neurons Its role in neurodevelopment and brain function is essential for cognitive processes and memory formation Dysregulation of NR2E1 has been linked to neurodegenerative diseases and brain tumors, where it may contribute to tumorigenesis by disrupting the regulation of neural cell differentiation and survival In addition, NR2E1 has been implicated in the regulation of circadian rhythms and synaptic plasticity, making it a potential target for therapies aimed at treating neurological and psychiatric disorders
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