Nuclear Receptor Subfamily 2 Group C Member 2 (NR2C2) Antibody
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Description
Members of the nuclear hormone receptor family, such as NR2C2, act as ligand-activated transcription factors. The proteins have an N-terminal transactivation domain, a central DNA-binding domain with 2 zinc fingers, and a ligand-binding domain at the C terminus. The activated receptor/ligand complex is translocated to the nucleus where it binds to hormone response elements of target genes (Yoshikawa et al., 1996 [PubMed 8661150]).
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Nuclear Receptor Subfamily 2 Group C Member 2 (NR2C2) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000, IF/ICC: 1/10 - 1/50. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IF/ICC |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P49116 |
| NCBI Accession | NP_003289.2 |
| Alias | TR4,TAK1,Testicular receptor 4,Orphan nuclear receptor TR4,Orphan nuclear receptor TAK1 |
| Background | Antibody anti-NR2C2 |
| Status | RUO |
Descripción
Nuclear receptor subfamily 2 group C member 2 (NR2C2), also known as TR4, is a nuclear receptor involved in regulating various biological processes, including development, metabolism, and cellular differentiation NR2C2 functions by binding to specific DNA sequences, known as hormone response elements (HREs), and modulating the transcription of genes involved in processes like cell cycle regulation, lipid metabolism, and gene expression NR2C2 is expressed in tissues such as the liver, heart, and brain, where it contributes to the regulation of metabolic processes and cellular growth During development, NR2C2 plays a role in the regulation of neuronal differentiation and the development of the central nervous system Dysregulation of NR2C2 has been linked to disorders such as cancer, where its altered expression may influence tumor growth and metastasis In addition, NR2C2 is involved in regulating the immune system, and its dysfunction can lead to conditions like autoimmune diseases and inflammatory disorders, highlighting its importance in maintaining cellular and systemic homeostasis
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Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED(direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements(HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior(By similarity). Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation.
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