NR2C2 antibody
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | mitogen-activated protein kinase kinase kinase 7 (NR2C2) |
| Host | Rabbit |
| Reactivity | Human, Hamster, Mouse |
| Recommended Dilution | WB: 1:500-1:2000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 64-67 kDa, 75-80 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, IHC, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P49116 |
| Alias | TR4,TAK1,Testicular receptor 4,Orphan nuclear receptor TR4,Orphan nuclear receptor TAK1 |
| Background | Antibody anti-NR2C2 |
| Status | RUO |
| Note | Mol. Weight 64-67 kDa, 75-80 kDa |
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Human NR2C2 (Nuclear receptor subfamily 2 group C member 2) ELISA Kit
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NR2C2 antibody
Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED(direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements(HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior(By similarity). Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation.
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