Nuclear Receptor Subfamily 2 Group C Member 1 (NR2C1) Antibody
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935106861
info@markelab.com
Precio
292.5€ (80 µl)
Antibody anti-NR2C1
proveedor
Abbexareference
abx028626Tested Applications
ELISA, WBreactivity
Humanstatus
RUOclonality
PolyclonalDescripción
This gene encodes a nuclear hormone receptor characterized by a highly conserved DNA binding domain (DBD), a variable hinge region, and a carboxy-terminal ligand binding domain (LBD) that is typical for all members of the steroid/thyroid hormone receptor superfamily. This protein also belongs to a large family of ligand-inducible transcription factors that regulate gene expression by binding to specific DNA sequences within promoters of target genes. Multiple alternatively spliced transcript variants have been described, but the full-length nature of some of these variants has not been determined.
Background
Nuclear receptor subfamily 2 group C member 1 (NR2C1), also known as TR2, is a nuclear receptor that is involved in regulating various biological processes, including development, metabolism, and cellular differentiation NR2C1 is expressed in a variety of tissues, including the brain, liver, and reproductive organs, where it plays a role in regulating the expression of genes involved in lipid metabolism, steroidogenesis, and cellular growth It functions by binding to specific DNA sequences and modulating the transcription of target genes, influencing both developmental processes and the regulation of metabolic pathways NR2C1 also plays a role in the regulation of the immune system, where it helps control the expression of genes involved in immune responses and inflammation Dysregulation of NR2C1 has been associated with disorders such as cancer, where altered nuclear receptor activity can contribute to tumor progression and metastasis Additionally, NR2C1 is implicated in the regulation of circadian rhythms and reproductive health, highlighting its importance in maintaining cellular and systemic homeostasis Its involvement in development, metabolism, and immune function positions NR2C1 as a potential therapeutic target for diseases related to hormonal imbalances, inflammation, and cancer
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human
immunogen target
Nuclear Receptor Subfamily 2 Group C Member 1 (NR2C1)
host
Rabbit
isotype
IgG
conjugation
Unconjugated
form
Liquid
tested applications
ELISA, WB
purification
Purified through a protein A column, followed by peptide affinity purification.
recommended dilution
WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
buffer
PBS containing 0.09% sodium azide.
size 1
80 µl
size 2
400 µl
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
NR2C1
dry ice
No
availability
Shipped within 5-10 working days.
alias
TR2,Orphan nuclear receptor TR2,Testicular receptor 2
uniprot id
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