NR2C1 antibody
Contáctenos para saber el precio
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
NR2C1 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab05840
tested applications
ELISA, WB, IHC
Description
Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements(HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED(direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiation. Mediator of retinoic acid-regulated preadipocyte proliferation.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | nuclear receptor subfamily 2, group C, member 1 (NR2C1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 52kd |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P13056 |
| Gene ID | 7181 |
| Alias | TR2,Orphan nuclear receptor TR2,Testicular receptor 2 |
| Background | Antibody anti-NR2C1 |
| Status | RUO |
| Note | Mol. Weight 52 kDa |
Descripción
Nuclear receptor subfamily 2 group C member 1 (NR2C1), also known as TR2, is a nuclear receptor that is involved in regulating various biological processes, including development, metabolism, and cellular differentiation NR2C1 is expressed in a variety of tissues, including the brain, liver, and reproductive organs, where it plays a role in regulating the expression of genes involved in lipid metabolism, steroidogenesis, and cellular growth It functions by binding to specific DNA sequences and modulating the transcription of target genes, influencing both developmental processes and the regulation of metabolic pathways NR2C1 also plays a role in the regulation of the immune system, where it helps control the expression of genes involved in immune responses and inflammation Dysregulation of NR2C1 has been associated with disorders such as cancer, where altered nuclear receptor activity can contribute to tumor progression and metastasis Additionally, NR2C1 is implicated in the regulation of circadian rhythms and reproductive health, highlighting its importance in maintaining cellular and systemic homeostasis Its involvement in development, metabolism, and immune function positions NR2C1 as a potential therapeutic target for diseases related to hormonal imbalances, inflammation, and cancer
Related Products
Human NR2C1 (Nuclear receptor subfamily 2 group C member 1) ELISA Kit
Ver Producto
NR2C1 antibody
Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements(HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED(direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiation. Mediator of retinoic acid-regulated preadipocyte proliferation.
Ver Producto
Nuclear Receptor Subfamily 2 Group C Member 1 (NR2C1) Antibody
NR2C1 Antibody is a Rabbit Polyclonal Antibody against NR2C1.
Ver Producto