Nuclear Receptor Subfamily 0 Group B Member 1 (NR0B1) Antibody
377€ (100 µg)
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Name
Nuclear Receptor Subfamily 0 Group B Member 1 (NR0B1) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx232248
Tested Applications
ELISA, WB, IHC, IF/ICC
Description
DAX-1 Antibody is a Rabbit Polyclonal against DAX-1.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Nuclear Receptor Subfamily 0 Group B Member 1 (NR0B1) Immunogen: nuclear receptor subfamily 0, group B, member 1 |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: 2 mg/ml |
| Recommended Dilution | WB: 1/200 - 1/1000, IHC: 1/20 - 1/200, IF/ICC: 1/50 - 1/500. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Observed MW: 54 kDa |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P51843 |
| Gene ID | 190 |
| OMIM | 300018 |
| Alias | AHC,AHX,DSS,GTD,HHG,AHCH,DAX1,DAX-1,NROB1,SRXY2,Nuclear receptor DAX-1,DSS-AHC critical region on the X chromosome protein 1 |
| Background | Antibody anti-NR0B1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Nuclear receptor subfamily 0 group B member 1 (NR0B1), also known as DAX-1, is a nuclear receptor that plays a crucial role in the regulation of endocrine function, particularly in the development and function of the gonads and adrenal glands NR0B1 acts as a transcriptional regulator by binding to DNA and influencing the expression of target genes involved in steroidogenesis, sexual differentiation, and reproductive function It functions primarily by repressing the activity of other nuclear receptors, such as steroid hormone receptors, and plays a key role in controlling the balance of sex hormones and their effects on the body NR0B1 is essential for the proper development of the hypothalamic-pituitary-gonadal axis, and mutations in the NR0B1 gene have been associated with disorders such as 46, XY gonadal dysgenesis, a condition that results in underdeveloped gonads and infertility Additionally, NR0B1 is involved in regulating the development of the central nervous system and the regulation of bone metabolism Dysregulation of NR0B1 has been linked to several endocrine disorders and cancers
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