Nuclear receptor ROR-beta (RORb) Antibody (HRP)

Background

RAR related orphan receptor B (RORB) is another member of the ROR family of nuclear receptors, playing a critical role in regulating the development of the central nervous system and circadian rhythms RORB is particularly important for the development of the retina and the regulation of visual processing, where it modulates the expression of genes involved in retinal cell differentiation and function It also participates in regulating the transcription of genes related to metabolism and cell growth, affecting cellular differentiation in multiple tissues RORB is involved in the regulation of sleep-wake cycles by modulating the circadian clock and influencing the expression of key clock genes Disruption in RORB expression is linked to several neurological disorders, including sleep disturbances and retinal degeneration, and may contribute to diseases like bipolar disorder and schizophrenia Its role in neurodevelopment and circadian regulation makes RORB a target for therapies aimed at treating neurological diseases and circadian rhythm disorders