Nuclear pore complex protein Nup153 (NUP153) Antibody
299€ (50 µl)
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Name
Nuclear pore complex protein Nup153 (NUP153) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx402586
Tested Applications
ELISA, IHC, IF/ICC
Description
Nuclear pore complex protein Nup153 (NUP153) Antibody is a Recombinant Rabbit Monoclonal antibody for the detection of Human NUP153.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Nuclear pore complex protein Nup153 (NUP153) Immunogen: A synthesized peptide derived from human Nup153 |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | IHC: 1/50 - 1/200, IF/ICC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Expression | Recombinant |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, IHC, IF/ICC |
| Buffer | PBS, pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P49790 |
| Gene ID | 9972 |
| OMIM | 603948 |
| Alias | N153,HNUP153,nucleoporin 153kDa,Nuclear pore complex protein Nup153 |
| Background | Antibody anti-NUP153 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Nucleoporin 153 (NUP153) is an essential component of the nuclear pore complex (NPC) that plays a significant role in nucleocytoplasmic transport NUP153 is involved in the structural maintenance of the NPC and aids in the selective trafficking of proteins, RNA, and ribosomal subunits across the nuclear envelope It functions as an anchor point for other nucleoporins, stabilizing the nuclear pore structure and facilitating the proper exchange of molecules between the nucleus and cytoplasm NUP153 also participates in the regulation of gene expression, ensuring the efficient export of mRNA from the nucleus to the cytoplasm for translation During cell division, NUP153 helps maintain nuclear envelope integrity, ensuring proper nuclear compartmentalization and cell cycle progression Dysregulation of NUP153 has been linked to various diseases, including cancers and neurodegenerative disorders, where faulty nuclear transport can disrupt cellular processes, leading to genomic instability and abnormal cell proliferation
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